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Occurrence of melanoma in "dysplastic" nevus spilus: report of case and analysis by flow cytometry
R S Kurban1, F I Preffer, A J Sober
1Pathology Department, Massachusetts General Hospital, Harvard Medical School, Boston.
Journal of Cutaneous Pathology
|October 11, 1992
Abstract:
We report a case of melanoma arising in a large nevus spilus. On histologic examination, the nevus spilus had diagnostic features of melanocytic dysplasia. Further characterization by flow cytometry showed DNA-aneuploidy within the melanoma as well as in one of the darker pigmented papules within the nevus spilus. The significance of this finding and a review of melanomas originating in nevi spili are presented.