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Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057
E Limburg1, R Gahlmann, H-P Kroll
1Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany.
Antimicrobial Agents and Chemotherapy
|January 27, 2004
Abstract:
TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.