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Minimum alveolar concentration (MAC) of xenon in intubated swine

K E Hecker1, N Horn, J H Baumert

  • 1Department of Anaesthesiology, Klinikum der RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany. klaus.hecker@post.rwth-aachen.de

British Journal of Anaesthesia
|January 27, 2004
PubMed
Abstract

Insights

The minimum alveolar concentration (MAC) of xenon (Xe) in swine was determined to be 119 vol. %. This study provides crucial data on xenon

Area of Science:

  • Anesthesiology
  • Veterinary Anesthesia
  • Pharmacology

Background:

  • The minimum alveolar concentration (MAC) is a standard measure of inhaled anesthetic hypnotic potency.
  • Understanding the MAC of xenon (Xe) is essential for evaluating its anesthetic and potential adverse effects.
  • A swine model is utilized for this investigation due to its physiological relevance.

Purpose of the Study:

  • To determine the minimum alveolar concentration (MAC) of xenon (Xe) in a swine model.
  • To establish the hypnotic potency of xenon as an inhalational anesthetic in swine.

Main Methods:

  • Ten swine (27.8-35.4 kg) were anesthetized using halothane and varying concentrations of xenon (0-65%).
  • A supramaximal pain stimulus (claw clamp) was applied to assess withdrawal reactions at each xenon concentration.
  • A logistic regression model was employed to calculate the MAC of xenon (MAC(Xe)) in the presence of halothane.

Main Results:

  • The calculated MAC(Xe) in swine was 119 vol. % under stable ventilation, hemodynamic, and temperature conditions.
  • The 95% confidence limits for MAC(Xe) were determined to be 103-135 vol. %.

Conclusions:

  • The minimum alveolar concentration of xenon (MAC(Xe)) in swine was extrapolated using a logistic regression model.
  • The theoretical value for MAC(Xe) in swine is established at 119 vol. %.

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