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Fish oil interaction with warfarin.

Mitchell S Buckley1, Angela D Goff, Walter E Knapp

  • 1Shawnee Mission Medical Center, Shawnee Mission, KS of Arizona, Tucson, AZ 85724, USA. mitchbuckley@hotmail.com

The Annals of Pharmacotherapy
|January 27, 2004
PubMed
Summary
This summary is machine-generated.

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Fish oil supplementation can increase warfarin

Area of Science:

  • Pharmacology
  • Nutritional Science

Background:

  • Warfarin is a common anticoagulant medication.
  • Fish oil is a popular dietary supplement rich in omega-3 fatty acids.

Observation:

  • A patient on stable warfarin therapy experienced a significant increase in international normalized ratio (INR) after doubling her fish oil dose.
  • The INR rose from 2.8 to 4.3 within one month of increasing fish oil intake.
  • Reducing the fish oil dose led to a decrease in INR.

Findings:

  • Fish oil, containing omega-3 polyunsaturated fatty acids, may potentiate warfarin's anticoagulant effect.
  • Potential mechanisms include effects on platelet aggregation and vitamin K-dependent coagulation factors.
  • This case suggests fish oil can have additive anticoagulant effects with warfarin.

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Implications:

  • Patients on warfarin should be monitored for potential interactions with fish oil supplements.
  • Healthcare providers should inquire about fish oil use in patients taking warfarin.
  • Increased awareness of fish oil's anticoagulant potential is crucial for safe anticoagulation management.