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Use of beta-blockers in patients with COPD
Miranda R Andrus1, Katherine P Holloway, Deidre B Clark
1Harrison School of Pharmacy, Auburn University, Tuscaloosa, AL, USA. mandrus@cchs.ua.edu
Objective:
To evaluate the safety and cardiovascular benefits of beta-blocker therapy in patients with chronic obstructive pulmonary disease (COPD).
Data Sources:
Clinical literature was accessed through MEDLINE (1966-February 2003). Key search terms included chronic obstructive pulmonary disease and adrenergic beta-antagonists.
Data Synthesis:
beta-Blockers are often avoided in patients with COPD because of fear of bronchoconstriction, despite the known cardiovascular mortality benefits. A review of studies evaluating the use of beta-blockers in COPD was undertaken.
Conclusions:
The literature supports the safety and mortality benefits of using beta-blockers in COPD. Patients with mild to moderate COPD should receive cardioselective beta-blocker therapy when a strong indication exists.