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Related Experiment Videos

Heparin-induced hyponatremia.

N Elizabeth Norman1, Angela M Sneed, Christine Brown

  • 1Department of Pharmacy, The Regional Medical Center at Memphis, TN 38103-2807, USA. enorman@the-med.org

The Annals of Pharmacotherapy
|January 27, 2004
PubMed
Summary
This summary is machine-generated.

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Unfractionated heparin (UFH) therapy can cause significant hyponatremia and hyperkalemia by antagonizing aldosterone. These electrolyte disturbances resolve after discontinuing UFH.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Parenteral nutrition is used for postoperative ileus.
  • Unfractionated heparin (UFH) is used for pulmonary embolism.
  • Electrolyte imbalances can occur with UFH therapy.

Observation:

  • A 70-year-old woman on UFH and parenteral nutrition developed hyponatremia and mild hyperkalemia.
  • Serum sodium declined, and urine sodium increased during UFH treatment.
  • No signs of fluid overload or deficit were present.

Findings:

  • UFH therapy was associated with hyponatremia and hyperkalemia.
  • The adverse drug reaction was deemed probable.
  • Aldosterone antagonism by UFH in the adrenal zona glomerulosa is the proposed mechanism.

Related Experiment Videos

Implications:

  • UFH can cause significant hyponatremia and hyperkalemia.
  • Monitoring electrolytes is crucial during UFH therapy.
  • Discontinuation of UFH leads to reversal of electrolyte abnormalities.