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Canine prostatic intraepithelial neoplasia: is the comparative model relevant?
Bruce R Madewell1, Regina Gandour-Edwards, Ralph W DeVere White
1Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA. brmadewell@ucdavis.edu
The Prostate
|January 27, 2004
Summary
Canine high-grade prostatic intraepithelial neoplasms (HGPIN) are rarely found in healthy or hyperplastic prostates. HGPIN was detected alongside prostate cancer in over a third of cases, impacting its use in chemoprevention research.
Area of Science:
- Veterinary Pathology
- Oncology
- Comparative Medicine
Background:
- Canine high-grade prostatic intraepithelial neoplasms (HGPIN) are a potential model for human prostate cancer.
- Understanding HGPIN detection is crucial for developing chemopreventive strategies in dogs.
Purpose of the Study:
- To assess the detectability of canine HGPIN in clinically obtained prostate samples.
- To evaluate the utility of the canine model for prostate cancer chemoprevention research.
Main Methods:
- Histologic examination of archived canine prostate tissue specimens.
- Inclusion of normal, benign prostatic hyperplasia, and prostatic carcinoma tissues.
- Analysis of HGPIN presence in a single tissue plane.
Main Results:
- No HGPIN detected in 20 normal prostate glands.
- No HGPIN detected in 95 prostate glands with benign prostatic hyperplasia.
- HGPIN found in 7 out of 20 (35%) canine prostatic carcinomas.
Conclusions:
- Clinically procured biopsies of healthy or hyperplastic canine prostates are unlikely to reveal HGPIN.
- The utility of canine HGPIN for temporal studies in prostate cancer chemoprevention may be limited.
- HGPIN frequently co-occurs with canine prostatic carcinoma, suggesting a potential precursor relationship.