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The Riken mouse genome encyclopedia project.

Yoshihide Hayashizaki1

  • 1Gene Exploration Research Group, Riken Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. yosihide@gsc.riken.go.jp

Comptes Rendus Biologies
|January 28, 2004
PubMed
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The Riken mouse genome encyclopedia provides a comprehensive database of mouse full-length cDNA, aiding in gene discovery and network analysis. This resource facilitates understanding of gene function and regulation in mammals.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • The mouse is a key model organism for studying mammalian genetics and disease.
  • A comprehensive understanding of the mouse genome is crucial for advancing biological research.
  • Existing cDNA collections and databases have limitations in scope and annotation.

Purpose of the Study:

  • To create a comprehensive full-length cDNA collection and sequence database for the mouse genome.
  • To provide high-level functional annotation for mouse genes.
  • To demonstrate the utility of this database for biological research applications.

Main Methods:

  • Generation of over 1,000,000 cDNA clones from 163 mouse tissues.
  • End-sequencing and clustering of clones into 128,000 groups.

Related Experiment Videos

  • Full sequencing of 60,000 representative clones.
  • Functional annotation using sequence homology, expression profiling, mapping, and protein-protein interactions.

    • Main Results:

    • Establishment of the Riken mouse genome encyclopedia, a valuable resource for the scientific community.
    • Identification of 24,000 clear protein-encoding genes.
    • Development of a robust annotation system integrating multiple data types.
    • Successful application of the database for positional cloning and gene network analysis.

    Conclusions:

    • The Riken mouse genome encyclopedia represents a significant advancement in mouse genomics.
    • This comprehensive resource accelerates functional genomics studies and disease research.
    • The database is a powerful tool for exploring gene function, interactions, and regulatory networks.