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Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Osteopontin identified as colon cancer tumor progression marker
Deepak Agrawal1, Tingan Chen, Rosalyn Irby
1Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.
Abstract:
Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.
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