Aileen C McLeod1, David M J Lilley
1Cancer Research UK Nucleic Acid Structure Research Group, Department of Biochemistry, MSI/WTB Complex, The University of Dundee, UK.
The VS ribozyme efficiently ligates substrates in trans when a helix prevents dissociation. Nucleotide C755 is crucial for ligation, and pH affects reaction rates, suggesting protonation states influence catalysis.
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