Selection ability in Alzheimer's disease: investigation of a component of semantic processing

Selection ability (selecting a response from several competing semantic and/or lexical representations) was tested in 21 participants with Alzheimer's disease (AD) and 28 control participants to help clarify the nature of semantic impairments in AD. Selection demands were manipulated in 3 tasks (lexical fluency, comparison, and verb generation). In each, high-selection conditions required response selection from competing alternatives, whereas low-selection conditions had a reduced need for selection. Patients with AD were disproportionately impaired on the high-selection conditions of all tasks, even when this condition was easier. Selection deficits on verb generation were evident only relative to nonspeeded controls. Overall results indicate impaired semantic selection abilities in AD, which may contribute to poor performance on some semantic tasks.