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Updated: Jul 7, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Unraveling V(D)J recombination; insights into gene regulation
1Howard Hughes Medical Institute, The Children's Hospital, The CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
Abstract:
V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
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