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Updated: Aug 29, 2026

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
Published on: January 19, 2022
Metofluthrin: a potent new synthetic pyrethroid with high vapor activity against mosquitoes
Kazuya Ujihara1, Tatsuya Mori, Tomonori Iwasaki
1Agricultural Chemicals Research Laboratory, Sumitomo Chemical Co., Ltd, Hyogo, Japan. ujihara@ssc.sumitomo-chem.co.jp
Abstract:
(1R)-trans-Norchrysanthemic acid fluorobenzyl esters are synthesized and their structure-activity relationships are discussed. These esters show outstanding insecticidal activity against mosquitoes. In particular, the 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl analog (metofluthrin) exhibits the highest potency, being approximately forty times as potent as d-allethrin in a mosquito coil formulation when tested against southern house mosquitoes (Culex quinquefasciatus). Metofluthrin also exhibits a significant vapor action at room temperature.
