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Evolution of linear plasmids.

F Kempken¹, J Hermanns, H D Osiewacz

¹Ruhr-Universität Bochum, Lehrstuhl für Allgemeine Botanik, FRG.

Journal of Molecular Evolution

|December 1, 1992

Summary

Linear plasmids, found in fungi and plants, encode their own DNA and RNA polymerases. Analysis reveals conserved sequences and similar phylogenetic trees for these polymerases, confirming evolutionary relationships.

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Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Linear plasmids are unique genetic elements found in various eukaryotes like yeast, fungi, and plants.
Unlike other plasmids, they feature terminal inverted repeats, bound proteins, and encode their own polymerases.

Purpose of the Study:

To analyze conserved amino acid sequences of DNA and RNA polymerases encoded by linear plasmids.
To compare these sequences with related viral and cellular polymerases.
To establish phylogenetic trees for these polymerases to understand their evolutionary relationships.

Main Methods:

Sequence alignment of conserved amino acid regions of linear plasmid-encoded DNA and RNA polymerases.
Comparative analysis against a database of viral and cellular polymerases.
Phylogenetic tree construction using established computational methods.

Main Results:

Identified conserved amino acid sequences in both DNA and RNA polymerases from linear plasmids.
Demonstrated similarities in phylogenetic subgroupings between the DNA and RNA polymerase trees.
Confirmed the accuracy of the phylogenetic analysis method through consistent tree structures.

Conclusions:

The study provides insights into the evolutionary origins and relationships of polymerases encoded by linear plasmids.
Phylogenetic analysis supports a common ancestry or strong evolutionary linkage for these plasmid-encoded polymerases.
The findings contribute to understanding the diversity and evolution of genetic elements in eukaryotes.

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