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Updated: Aug 29, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
[Late manifestations of congenital diaphragmatic hernia]
1Klinika dĕtské chirurgie 2. LF UK Praha a FN Motol, Subkatedra dĕtské chirurgie IPVZ, Praha. mrygl@yahoo.com
Insights
Inborn diaphragmatic hernia in children can manifest late, causing respiratory and gastrointestinal issues. Early diagnosis and treatment are crucial, as acute strangulation is life-threatening.
Area of Science:
- Pediatric Surgery
- Congenital Abnormalities
- Thoracic Surgery
Context:
- Late-presenting congenital diaphragmatic hernia (CDH) requires evaluation after the neonatal period.
- This study examines clinical and anatomical features of pediatric CDH diagnosed beyond the newborn phase.
- CDH can present with non-acute symptoms or life-threatening emergencies.
Purpose:
- To assess clinical and anatomical characteristics of late-manifesting congenital diaphragmatic hernia in children.
- To understand the presentation, surgical management, and outcomes of pediatric CDH after the neonatal period.
Summary:
- The study analyzed 18 children (11 boys, 7 girls) aged 2-78 months with late CDH. Most cases (15) were non-acute, while 3 presented as emergencies.
- Posterolateral defects were common, often on the left (11/18). Organs involved included intestines (12), liver (7), and spleen (6). Primary repair was successful in 17 children.
- One patient with intestinal strangulation died post-operatively. The remaining children recovered without complications.
Impact:
- Highlights the importance of considering CDH in pediatric differential diagnosis for respiratory/gastrointestinal symptoms.
- Emphasizes that acute CDH strangulation post-neonatal period is a critical condition requiring prompt intervention.
- Provides insights into surgical repair techniques and outcomes for late-presenting pediatric diaphragmatic hernias.
Abstract:
The aim of the work was to evaluate clinical and anatomical features in children with late manifestations of inborn diaphragma hernia after the newborn period. The group included 11 boys and 7 girls at the age of two to 78 months during the time of diagnosis. The diaphragma hernia was diagnosed in 15 children during non-acute manifestations and in three children affected by emergencies. A posterior-lateral defect of diaphragma was on the left side in 11 children and in 7 children on the left. A hernia sac was found in 11 children. Organs protruding into thorax included intestinal loops in 12 children, liver in 7 subjects, spleen in 6 individuals, stomach in five and kidney, pancreas and omentum in one each. The defect in diaphragma was occluded by a primary plasty in 17 children, while a patch from Goretex was used once. An intestinal strangulation required resection of necrotic part of intestine, but the boy died one month later for a multi-organ failure despite long-term resuscitation care. The other children were cured up without complications. The inborn diaphragma hernia should be considered in differential diagnosis of every child with unusual respiratory or gastrointestinal symptoms and abnormal X-ray picture of thorax. Acute strangulation of inborn diaphragma hernia after the newborn period is a life-threatening disease, where the gastrointestinal obstruction is combined with respiratory and circulation failure.
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