Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic mastocytosis.

Cem Akin1, Dean D Metcalfe

  • 1Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. cakin@niaid.nih.gov

Annual Review of Medicine
|January 30, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychometric evaluation of the Mastocytosis Symptom Severity Daily Diary (MS2D2) in adults with nonadvanced systemic mastocytosis (NonAdvSM).

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Reply to "Chronic Spontaneous Urticaria: The Most Common MCAS-Like Disease".

The journal of allergy and clinical immunology. In practice·2026
Same author

Avapritinib achieves long-term disease control with favorable safety in patients with indolent systemic mastocytosis over 3 years.

The Journal of allergy and clinical immunology·2026
Same author

Anaphylaxis events in the PIONEER study of avapritinib in indolent systemic mastocytosis.

The World Allergy Organization journal·2026
Same author

Clinical relevance of mosaic variants detected by exome sequencing.

The Journal of allergy and clinical immunology·2026
Same author

Systemic Mastocytosis, KIT and the Effects of KIT Tyrosine Kinase Inhibitors on Mast Cell and Basophil Activation.

Current allergy and asthma reports·2026
Same journal

Dupilumab Emerges as an Effective Antibody Therapy for Eosinophilic Esophagitis.

Annual review of medicine·2026
Same journal

CAR T Cell Toxicities and Emerging Treatment Strategies.

Annual review of medicine·2026
Same journal

Transthyretin Amyloid Cardiomyopathy: A Rapidly Evolving Landscape.

Annual review of medicine·2026
Same journal

Accessibility of Somatic Genetic Testing for Cancer Treatment Decisions.

Annual review of medicine·2026
Same journal

Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management.

Annual review of medicine·2026
Same journal

Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium.

Annual review of medicine·2026
See all related articles

Systemic mastocytosis involves abnormal mast cell growth, causing symptoms due to their accumulation in organs. Research highlights key molecular differences, aiding diagnosis and new treatments for this mast cell disorder.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Systemic mastocytosis is a clonal disorder originating from mast cells or their progenitors.
  • Pathologic accumulation and activation of mast cells in organs like bone marrow, skin, and liver cause disease symptoms.

Purpose of the Study:

  • To highlight recent findings on the molecular and cellular biology of mast cells in systemic mastocytosis.
  • To explain how these findings inform diagnostic criteria and novel therapeutic strategies.

Main Methods:

  • Comparative analysis of mast cell molecular and cellular biology between patients and healthy individuals.
  • Review of recent scientific literature and studies.

Main Results:

  • Striking differences identified in the molecular and cellular biology of mast cells in patients with systemic mastocytosis compared to healthy subjects.

Related Experiment Videos

  • These differences provide a basis for improved understanding of the disease.

    • Conclusions:

    • Recent molecular and cellular findings are crucial for advancing the diagnosis of systemic mastocytosis.
    • These insights are paving the way for the development of innovative treatment approaches for patients.