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Related Experiment Videos

Tamoxifen optic neuropathy.

Stephen M Colley, John S Elston

    Clinical & Experimental Ophthalmology
    |January 30, 2004
    PubMed
    Summary
    This summary is machine-generated.

    Tamoxifen can cause optic neuropathy, leading to vision loss in metastatic breast cancer patients. Stopping tamoxifen treatment significantly improved vision in a patient with this condition.

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    Area of Science:

    • Ophthalmology
    • Oncology
    • Pharmacology

    Background:

    • Metastatic breast cancer treatment often involves endocrine therapy, such as tamoxifen.
    • Optic neuropathy is a potential, though rare, side effect of certain medications.
    • Visual disturbances can be a presenting symptom of various underlying conditions.

    Observation:

    • A 68-year-old woman with metastatic breast cancer experienced gradual vision loss in both eyes.
    • Electrophysiological testing confirmed bilateral optic neuropathies.
    • Standard investigations failed to identify the etiology of the visual impairment.

    Findings:

    • The patient's visual acuity dramatically improved after discontinuing tamoxifen therapy.
    • This suggests a causal link between tamoxifen use and the observed optic neuropathy.

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  • The condition appears to be reversible upon cessation of the causative agent.

    • Implications:

    • Tamoxifen should be considered as a potential cause of optic neuropathy in patients with breast cancer.
    • Ophthalmologists and oncologists should be vigilant for visual symptoms in patients on tamoxifen.
    • Early recognition and drug withdrawal may lead to visual recovery.