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Updated: Aug 29, 2026
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
Published on: January 18, 2019
A mathematical model for electrical stimulation of a monolayer of cardiac cells
Ranjini Srinivasan1, Bradley J Roth
1Department of Physics, Oakland University, Rochester, Michigan 48309 USA. sriniv33@msu.edu
Background:
The goal of our study is to examine the effect of stimulating a two-dimensional sheet of myocardial cells. We assume that the stimulating electrode is located in a bath perfusing the tissue.
Methods:
An equation governing the transmembrane potential, based on the continuity equation and Ohm's law, is solved numerically using a finite difference technique.
Results:
The sheet is depolarized under the stimulating electrode and is hyperpolarized on each side of the electrode along the fiber axis.
Conclusions:
The results are similar to those obtained previously by Sepulveda et al. (Biophys J, 55: 987-999, 1989) for stimulation of a two-dimensional sheet of tissue with no perfusing bath present.
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