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Updated: Jul 21, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
R Dolz Aspas1, P Samperiz Legarre, E Calvo Begueria
1Servicio de Medicina Interna B, Hospital Clínico Lozano Blesa, Zaragoza.
This study examined how often doctors can diagnose the cause of syncope, a sudden loss of consciousness, in hospitalized patients. Over two years, 79 patients were admitted for syncope, and only 67% received a clear diagnosis. Many tests, like EEGs and CT scans, were performed but rarely helped identify the cause. The researchers found that diagnostic algorithms based on patient history and basic tests could reduce unnecessary procedures. The main takeaway is that current testing practices may be inefficient, and a more structured approach could improve outcomes for syncope patients.
Area of Science:
Background:
Syncope remains a diagnostic challenge in clinical practice. Despite the availability of various diagnostic tools, a significant proportion of patients receive no clear diagnosis after hospitalization. Prior research has shown that diagnostic tests are often used without clear guidelines, leading to unnecessary procedures. It was already known that syncope affects a wide age range, but the exact diagnostic yield of specific tests remained unclear. No prior work had resolved the extent to which diagnostic algorithms could reduce test overuse. This gap motivated a review of patient records to assess diagnostic success and test utilization. The study aimed to clarify how frequently tests contribute to diagnosis versus being performed unnecessarily. The focus was on identifying patterns in test use and diagnostic outcomes. The goal was to inform more efficient diagnostic strategies for syncope.
Purpose Of The Study:
The study aimed to evaluate the diagnostic success of various tests in syncope patients and identify patterns of test overuse. The specific problem addressed was the high rate of undiagnosed syncope despite extensive testing. The motivation stemmed from the need to improve diagnostic efficiency and reduce unnecessary procedures. The researchers sought to determine which tests provided meaningful results and which were frequently performed without benefit. The study focused on a two-year cohort of hospitalized syncope patients. The goal was to assess the diagnostic yield of cardiology and neurological tests. The researchers also aimed to propose a more rational diagnostic approach. The ultimate purpose was to inform clinical guidelines for syncope evaluation.
Main Methods:
The researchers conducted a retrospective analysis of syncope admissions in an internal medicine service. The study period spanned two years, from 1999 to 2000. A total of 79 patients were included out of 2,878 hospitalized individuals. Patient demographics and test outcomes were extracted from medical records. Diagnostic tests were categorized by specialty—cardiology and neurology. The frequency of each test was recorded and compared to diagnostic success. The researchers assessed whether test results led to a definitive diagnosis. No new diagnostic tools were introduced; the analysis focused on existing procedures. The goal was to identify patterns of test use and diagnostic yield.
Main Results:
An etiological diagnosis was established in 53 of 79 patients (67%). Neurological mechanisms accounted for 31.6% of cases, while cardiology origins were found in 20.25%. Neurological causes were identified in 5.06% of patients, and other causes in 10.1%. Cardiology tests were performed in 68.8% of patients, including 41 Holter, 32 echocardiograms, and 6 tilt board tests. Neurological tests were performed in 64% of patients, including 31 EEGs and 42 CT scans. Only 4 Holter tests, 3 echocardiograms, and 2 CT scans provided diagnostic information. No EEGs contributed to a definitive diagnosis. The researchers found excessive use of EEGs, Holter monitoring, and cerebral CT scans. Despite extensive testing, 33% of patients remained undiagnosed.
Conclusions:
The authors propose that diagnostic algorithms based on clinical history, physical examination, and ECG findings could improve syncope diagnosis. The study suggests that current diagnostic practices involve excessive use of certain tests without diagnostic benefit. The findings indicate that EEGs, Holter monitoring, and cerebral CT scans are frequently performed without yielding useful results. The authors emphasize the need for a more rational diagnostic approach to reduce unnecessary testing. The study supports the use of detailed clinical evaluation as a starting point. No essential role was assigned to any single test in the diagnostic process. The researchers suggest that a structured algorithm could guide diagnostic decisions. The ultimate implication is that improved diagnostic strategies may reduce test overuse.
The study found that 67% of syncope patients received an etiological diagnosis, while 33% remained undiagnosed despite extensive testing.
Only 4 Holter tests, 3 echocardiograms, and 2 CT scans provided definitive diagnoses, while EEGs showed no diagnostic benefit.
The authors found that no EEGs contributed to a definitive diagnosis of syncope, suggesting their limited utility in this context.
The authors suggest using clinical history, physical examination, and ECG findings to guide diagnostic decisions and reduce unnecessary tests.
68.8% of patients had at least one cardiology test, including 41 Holter and 32 echocardiograms.
The authors propose that diagnostic algorithms could improve efficiency and reduce overuse of tests like EEGs and CT scans.