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Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Takeshi Suzuki1, Ryoichi Takagi, Koichiro Kawashima

  • 1Department of Pharmacology, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. suzuki-tk@kyoritsu-ph.ac.jp

Neuroscience Letters
|January 30, 2004
PubMed

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Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...