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Related Experiment Videos

Ciliary neurotrophic factor (CNTF) genotype and body composition.

Ashok C Jacob1, Joseph M Zmuda, Jane A Cauley

  • 1Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, MD 20742, USA.

European Journal of Human Genetics : EJHG
|January 30, 2004
PubMed
Summary

This study found no link between the ciliary neurotrophic factor (CNTF) null allele and body weight or composition in US cohorts. These findings contradict previous European research on CNTF genotype and body mass index (BMI).

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Area of Science:

  • Genetics and Human Physiology
  • Metabolic Research
  • Population Health Studies

Background:

  • Exogenous ciliary neurotrophic factor (CNTF) administration is known to cause weight loss.
  • The impact of endogenous CNTF and the CNTF null allele on body composition remains unclear.
  • A prior European study suggested a link between the CNTF null allele and higher body weight/BMI in older males.

Purpose of the Study:

  • To investigate the association between the CNTF null allele and body composition.
  • To replicate or refute findings from a European cohort regarding CNTF genotype and body weight/BMI.

Main Methods:

  • Analysis of three US-based cohorts: Baltimore Longitudinal Study on Aging (BLSA) and Study of Osteoporotic Risk in Men (STORM).
  • Genotyping for the CNTF null allele (A/A genotype).

Related Experiment Videos

  • Assessment of body weight, body mass index (BMI), total body fat, and fat-free mass in relation to CNTF genotype.

    • Main Results:

    • No significant association was detected between CNTF genotype and body weight in any of the studied cohorts (BLSA, STORM, combined).
    • Similarly, no significant association was found between CNTF genotype and BMI across the cohorts.
    • The CNTF genotype did not show a significant association with total body fat or fat-free mass in the BLSA cohort.

    Conclusions:

    • The results do not support a role for the CNTF null allele in influencing body composition in the studied US populations.
    • These findings contrast with previous research suggesting an association between the CNTF null allele and increased body weight/BMI.