Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Endometriosis: a genetic disease.

Rene Wenzl¹, Ludwig Kiesel, Johannes C Huber

¹Department of Gynecologic Endocrinology and Reproduction, University of Vienna School of Medicine, Vienna, Austria. rene.wenzl@akh-wien.ac.at

Drugs of Today (Barcelona, Spain : 1998)

|January 30, 2004

Summary

Genetic factors significantly influence endometriosis, a condition where uterine lining grows outside the uterus. Identifying genetic variants and mutations can personalize therapies and prevention strategies for women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional Analysis of the Histidine N-Methyltransferase SETD3 in Endometriosis.

International journal of molecular sciences·2026

Same author

Radiological over- and underestimation of DCIS extent in breast conserving surgery specimens: radiological-pathological correlation in slice radiographs and respective histological large-format slides.

Human pathology·2026

Same author

Initial Results of FAPI PET/MRI to Assess the Extent of Endometriosis.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Same author

Predicting superficial peritoneal endometriosis in symptomatic women with negative examination and imaging.

Fertility and sterility·2026

Same author

Margin status in ductal carcinoma in situ of the breast: radiological-pathological correlation in slice radiographs and histological large-format slides of breast conserving surgery specimens.

Human pathology·2026

Same author

The estrobolome and its emerging role in endometriosis pathogenesis: no guts, no story?

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2026

Area of Science:

Reproductive Medicine
Genetics
Immunology

Background:

Endometriosis affects up to 15% of reproductive-aged women.
Characterized by endometrial cells growing outside the uterus.
Susceptibility involves immunologic, hormonal, environmental, and genetic factors.

Purpose of the Study:

Investigate the influence of genetic variants on endometriosis.
Identify genes pivotal to endometriosis development.
Explore genetic factors for personalized therapies and prevention.

Main Methods:

Utilizing technologies like subtractive cDNA hybridization, DNA chip technology, and differential display polymerase chain reaction.
Conducting systematic searches for gene perturbations using polymerase chain reaction.

Related Experiment Videos

Performing association studies on candidate genes related to cancer, hormone sensitivity, and immunology.

Main Results:

Novel association studies identified candidate genes influencing endometriosis.
Analysis of mutations and polymorphisms in specific genes.
Exploration of genetic links to endometriosis susceptibility.

Conclusions:

Genetic variants play a crucial role in endometriosis.
Understanding genetic factors can lead to individualized treatment approaches.
Genetic assessment may enable targeted prevention strategies for high-risk populations.