Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nucleic acid nanotechnology-towards Angstrom-scale engineering.

Jesper Wengel1

  • 1Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark. jwe@chem.sdu.dk

Organic & Biomolecular Chemistry
|January 30, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-gene oligonucleotides targeting Friedreich's ataxia expanded GAA⋅TTC repeats increase Frataxin expression.

Molecular therapy. Nucleic acids·2025
Same author

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i>/<i>Tec</i> double deficient X-linked agammaglobulinemia model.

RSC chemical biology·2025
Same author

Engineered PepFect14 analog for efficient cellular delivery of oligonucleotides.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Anti-gene oligonucleotide clamps invade dsDNA and downregulate <i>huntingtin</i> expression.

Molecular therapy. Nucleic acids·2025
Same author

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.

Bioconjugate chemistry·2024
Same author

Chemical Modifications and Design Influence the Potency of <i>Huntingtin</i> Anti-Gene Oligonucleotides.

Nucleic acid therapeutics·2023

Nucleic acid nanotechnology enables the creation of stable, nanometer-sized materials through self-assembly. This Angstrom-scale engineering approach allows for precise functionalization, paving the way for advanced applications in biology and materials science.

Area of Science:

  • * Nanotechnology
  • * Materials Science
  • * Chemical Engineering

Background:

  • * Nucleic acids and their analogues are effective building blocks for self-assembling nanometer-scale materials.
  • * Angstrom-scale chemical engineering is crucial for mimicking natural systems in size and function.
  • * Nucleic acid nanotechnology focuses on creating precise, functional nanostructures.

Purpose of the Study:

  • * To explore the potential of nucleic acids for creating stable, self-assembled nanostructures.
  • * To advance Angstrom-scale chemical engineering for biological and material science applications.
  • * To develop predictable spatial positioning of functionalities within nucleic acid architectures.

Main Methods:

  • * Utilizing nucleic acids and analogues as primary building blocks.

Related Experiment Videos

  • * Employing self-assembly principles for material construction.
  • * Focusing on Angstrom-scale precision in chemical engineering.

    • Main Results:

    • * Demonstrated the suitability of nucleic acids for reliable self-assembly into 2D and 3D nanostructures.
    • * Highlighted the emergence of Angstrom-scale chemical engineering for advanced nanotechnology.
    • * Showcased the development of rigid, stable nanostructures with predictable functional positioning.

    Conclusions:

    • * Nucleic acid nanotechnology offers a pathway to engineer functional architectures at the nanoscale.
    • * Precise spatial control over functionalities enables advanced applications in biological and material sciences.
    • * Angstrom-scale engineering is key to achieving nature-mimicking size and function in synthetic materials.