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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
[Intratympanic gentamicin treatment for intractable Menière's disease]
D Gilony1, M Wolf, J Kronenberg
1Departments of Otorhinolaryngology, Head & Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer.
Harefuah
|January 30, 2004
Summary
Intratympanic gentamicin injections effectively treat Meniere's disease vertigo attacks in 87% of patients, offering a safe, high-success alternative to surgery. This treatment provides significant functional recovery with minimal risk of hearing loss.
Area of Science:
- Otolaryngology
- Neurology
- Vestibular Disorders
Context:
- Meniere's disease often causes debilitating vertigo attacks.
- Intratympanic gentamicin is increasingly used for intractable cases.
- Treatment protocols vary across medical centers.
Purpose:
- To evaluate the efficacy of intratympanic gentamicin injections for vertigo control and functional recovery in Meniere's disease.
- To assess the safety profile, including hearing status and vestibular function.
- To review existing literature on gentamicin treatment for Meniere's disease.
Summary:
- A study of 23 patients with Meniere's disease treated with monthly intratympanic gentamicin injections.
- 87% of patients achieved vertigo control, and 69.6% reported full functional recovery.
- Significant vestibular weakness was observed post-treatment, but hearing deterioration was minimal, with no infections or perforations.
Impact:
- Intratympanic gentamicin offers a safe and effective treatment option for intractable Meniere's disease, reducing vertigo and improving function.
- The procedure has a high success rate and a low risk of hearing loss, making it a viable alternative to surgery.
- This approach can significantly improve the quality of life for patients suffering from chronic vertigo.
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