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Challenges facing antiangiogenic therapy for cancer: impact of the tumor extracellular environment

Paul Gagne1, Abebe Akalu, Peter C Brooks

  • 1New York University School of Medicine, Department of Surgery, New York, NY 10016, USA.

Expert Review of Anticancer Therapy
|January 30, 2004
PubMed

Insights

Angiogenesis is crucial for tumor growth. This review examines antiangiogenic therapies, focusing on the tumor microenvironment and clinical challenges for treating malignancies.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Angiogenesis, the formation of new blood vessels, is vital for malignant tumor progression.
  • Significant research targets novel angiogenesis inhibitors for human cancer treatment.

Purpose of the Study:

  • To review the role of angiogenesis in tumor growth.
  • To examine the development and clinical application of antiangiogenic therapies.
  • To explore challenges in antiangiogenic therapy, including tumor microenvironment, resistance, and clinical trial design.

Main Methods:

  • Literature review of angiogenesis and antiangiogenic therapies.
  • Analysis of the tumor microenvironment's impact on treatment efficacy.
  • Discussion of clinical challenges and optimization strategies.

Main Results:

  • Angiogenesis is a key driver of tumor progression.
  • Antiangiogenic therapies face challenges related to tumor microenvironment variability and resistance.
  • Optimization of clinical trial design is crucial for effective antiangiogenic therapy.

Conclusions:

  • Understanding the dynamic tumor microenvironment is essential for improving antiangiogenic therapies.
  • Addressing toxicities and resistance mechanisms can enhance treatment outcomes.
  • Further research is needed to optimize the clinical use of antiangiogenic agents for malignancies.

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