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Updated: Jul 29, 2026

Using Caco-2 Cells to Study Lipid Transport by the Intestine
Published on: August 20, 2015
Chylomicron metabolism
1Department of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia. redgrave@cyllene.uwa.edu.au
Abstract:
Chylomicrons are the 'orphans' of the lipoprotein family. Difficulty of measurement has impeded understanding of their metabolism. Plasma concentrations of chylomicrons and chylomicron remnants give no insight into the magnitude of substrate flux through these pathways. A defect in clearance of chylomicron remnants is probably an indication of a more generalized defect in lipoprotein metabolism. Accumulating evidence supports a relationship between abnormalities in the clearance from plasma of chylomicron remnants and accelerated progression of atherosclerosis. Methods using stable isotopes in appropriately formulated emulsions are providing valuable new information.
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