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Related Experiment Videos

Lipid oxidation in atherogenesis: an overview.

W Jessup1, L Kritharides, R Stocker

  • 1Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia. w.jessup@unsw.edu.au

Biochemical Society Transactions
|January 30, 2004
PubMed
Summary

The oxidation theory suggests oxidized lipids cause atherosclerosis. However, studies on antioxidants like Vitamin E show limited success, indicating more research is needed on oxidants and antioxidant properties.

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Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Pathology

Background:

  • Atherosclerosis development is linked to oxidized lipids and proteins.
  • Intimal low-density lipoprotein is a primary target for oxidation.
  • In vitro oxidized lipoproteins exhibit pro-atherogenic properties.

Purpose of the Study:

  • To evaluate the 'oxidation theory' of atherosclerosis.
  • To assess the efficacy of antioxidants, specifically Vitamin E, in preventing atherosclerosis.
  • To identify gaps in knowledge regarding oxidants and antioxidant actions in atherosclerosis.

Main Methods:

  • Review of studies investigating oxidized lipoproteins and their effects.
  • Analysis of evidence for oxidation products in atherosclerotic lesions.

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  • Examination of clinical and animal studies using Vitamin E for atherosclerosis prevention.

    • Main Results:

    • Oxidation products are detected in atherosclerotic lesions, though less oxidized than in vitro counterparts.
    • Vitamin E has shown limited anti-atherosclerotic potential in human and animal studies.
    • The specific oxidants driving lesion oxidation remain unidentified.

    Conclusions:

    • The oxidation theory requires further investigation due to unresolved questions about oxidants.
    • The complex antioxidant/pro-oxidant nature of Vitamin E may explain its limited efficacy.
    • More research is needed to fully test the oxidation theory of atherosclerosis.