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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

New clinical presentations of invasive aspergillosis in non-conventional hosts

D L Paterson1

  • 1Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, Pittsburgh, PA 15213, USA. patersond@msx.dept-med.pitt.edu

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|January 30, 2004
PubMed

Insights

Aspergillus infections commonly affect the lungs but can manifest unusually. Recognizing these rare invasive aspergillosis forms and initiating prompt treatment improves patient outcomes.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Invasive aspergillosis is typically a pulmonary infection.
  • Unusual presentations of invasive aspergillosis are increasingly reported.
  • These can include chronic pulmonary forms and extrapulmonary infections.

Purpose of the Study:

  • To review the spectrum of unusual invasive aspergillosis manifestations.
  • To highlight extrapulmonary and atypical pulmonary forms.
  • To emphasize the importance of early diagnosis and treatment.

Main Methods:

  • Literature review of reported cases of unusual invasive aspergillosis.
  • Analysis of clinical presentations and outcomes.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • Unusual pulmonary forms include chronic invasive pulmonary aspergillosis, bronchocentric granulomatosis, and tracheobronchitis.
  • Extrapulmonary manifestations occur, even in immunocompetent individuals.
  • Examples include vertebral osteomyelitis, primary cutaneous aspergillosis, prosthetic vascular graft infections, and infective endocarditis.

Conclusions:

  • Invasive aspergillosis can present with diverse and uncommon manifestations.
  • Prompt recognition and multidisciplinary management (antifungal therapy, surgery) are crucial.
  • Improved outcomes are associated with early diagnosis and intervention for these rare forms.

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