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Monogenic human obesity syndromes.

I S Farooqi1, S O'Rahilly

  • 1Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

Recent Progress in Hormone Research
|January 30, 2004
PubMed
Summary

Recent discoveries link single-gene defects to severe human obesity, mirroring findings in rodent models. This research explores these human monogenic obesity syndromes and their role in body weight and neuroendocrine regulation.

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Area of Science:

  • Endocrinology
  • Genetics
  • Obesity Research

Background:

  • Increased scientific focus on energy balance and obesity over the last decade.
  • Advances in identifying genes linked to obesity in animal models and humans.

Purpose of the Study:

  • To review characterized human monogenic obesity syndromes.
  • To assess the role of identified genes in human body weight and neuroendocrine regulation.

Main Methods:

  • Review of human monogenic obesity syndromes.
  • Comparison of human genetic defects with rodent obesity models.

Main Results:

  • Identification of several single-gene defects causing severe human obesity.
  • Many human defects involve molecules similar to those found in rodent obesity syndromes.

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Conclusions:

  • Human monogenic obesity syndromes provide insights into physiological pathways regulating body weight.
  • Genetic discoveries in rodents are relevant to understanding human obesity.