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A proposed mechanism of anticancer activity of indomethacin
1Institute of Endocrinology, Medical Academy of Lódź, Poland.
Medical Hypotheses
|November 1, 1992
Abstract:
The exact mechanism of anticancer activity of indomethacin still remains unclear. In view of the gathered observations and ideas, I hypothesize that the effect of indomethacin may be related--at least in certain cases--to its antagonism to gastrin/cholecystokinin family of peptides and/or to its agonistic activity to thromboxane A2 and melatonin. Future experiments in this direction are required.