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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 5, 2010
Recent development in genomic and proteomic research for asthma.
1Division of Respiratory and Pharmacogenomic Research, deCODE genetics, Inc., Reykjavik, Iceland.
Current Opinion in Pulmonary Medicine
|January 30, 2004
Summary
Recent asthma research reveals genetic links to asthma phenotypes like atopy and bronchial hyperresponsiveness. New gene discoveries are improving our understanding of this complex genetic disorder.
Area of Science:
- Genetics and Genomics
- Immunology
- Respiratory Medicine
Background:
- Asthma is a complex genetic disorder with diverse phenotypes.
- Environmental factors interact with multiple genes to influence asthma development.
Purpose of the Study:
- To review recent advancements in asthma genomic and proteomic research.
- To highlight new gene discoveries and their impact on understanding asthma.
Main Methods:
- Review of recent scientific literature on asthma genetics and proteomics.
- Analysis of studies reporting gene linkage and association with asthma phenotypes.
- Inclusion of postgenomic discoveries, including specific gene cloning.
Main Results:
- Numerous genetic loci and candidate genes associated with asthma, atopy, elevated immunoglobulin E (IgE), and bronchial hyperresponsiveness have been identified.
- While many associations exist, few genes conferring significant risk have been precisely mapped.
- Recent cloning of ADAM 33 and PHF11 provides new insights into asthma pathobiology.
Conclusions:
- The field of asthma genetics has advanced significantly, enhancing the understanding of its underlying pathobiology.
- Further research is exploring gene-gene interactions and the use of haplotypes to identify mutations and assess risk in complex disorders.
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