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CMV enteritis causing ileal perforation in underlying lupus enteritis.

Seungmin Bang1, Yong-Beom Park, Byung Seung Kang

  • 1Department of Internal Medicine, Institute for Immunology and Immunological Disease, BK 21 Project for Medical Science, Yonsei University College of Medicine, Shinchon-dong 134, Seodaemoon-gu, 120-752, Seoul, Korea.

Clinical Rheumatology
|January 30, 2004
PubMed
Summary

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This case study details a rare instance of cytomegalovirus (CMV) enteritis causing ileal perforation in a lupus enteritis patient. Prompt ganciclovir treatment led to symptom improvement.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Immunology

Background:

  • Lupus enteritis is an inflammatory condition affecting the small intestine in patients with systemic lupus erythematosus.
  • Cytomegalovirus (CMV) can cause gastrointestinal complications, particularly in immunocompromised individuals.

Observation:

  • A 31-year-old woman with lupus enteritis presented with severe abdominal pain, free air, and ileal wall thickening.
  • An emergency laparotomy revealed an ileal perforation with infarcted tissue.

Findings:

  • Histopathological examination of the surgical specimen confirmed the presence of cytomegalovirus inclusion bodies within the infarcted ileal lesion.
  • The patient's symptoms resolved after treatment with ganciclovir, an antiviral medication.

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Implications:

  • This case highlights a potential, previously unreported cause of ileal perforation in lupus enteritis patients.
  • Early diagnosis and antiviral therapy may be crucial for managing CMV enteritis in this specific patient population.