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Related Experiment Videos

Galanthamine pattern in Narcissus confusus plants.

Susana López1, Jaume Bastida, Francesc Viladomat

  • 1Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Planta Medica
|January 30, 2004
PubMed
Summary

Galanthamine, an alkaloid used for Alzheimer's disease, is found in Narcissus confusus plants. Its highest concentration occurs in the bulb during the emerging stage.

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Area of Science:

  • Pharmacognosy
  • Plant biochemistry
  • Medicinal chemistry

Background:

  • Galanthamine is a key Amaryllidaceae alkaloid with acetylcholinesterase inhibitory properties.
  • It is clinically utilized for managing Alzheimer's disease symptoms.

Purpose of the Study:

  • To investigate the distribution of galanthamine and four other alkaloids in Narcissus confusus organs.
  • To analyze alkaloid variations throughout the plant's ontogenic cycle.

Main Methods:

  • Qualitative and quantitative analysis of alkaloids in different plant organs (bulb, leaves, flowers).
  • Tracking alkaloid content across various developmental stages of Narcissus confusus.

Main Results:

  • Five alkaloids, including galanthamine, were detected in all plant organs and stages, except haemanthamine in senescent flowers.

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  • The highest total alkaloid content was observed in the bulb during the emerging stage.
  • Galanthamine was the most abundant alkaloid, reaching up to 2.5% of dry weight in the bulb.

    • Conclusions:

    • Narcissus confusus is a viable source of galanthamine.
    • Alkaloid accumulation in Narcissus confusus is organ- and stage-dependent, with bulbs at the emerging stage being the richest source.