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Published on: February 28, 2013
Diabetic neuropathy: an intensive review
Jeremiah John Duby1, R Keith Campbell, Stephen M Setter
1University of Arizona, Tucson, AZ, USA.
Summary
Diabetic neuropathy is a common diabetes complication affecting nerves, causing pain and dysfunction. Effective management involves glycemic control and various medications for symptom relief.
Area of Science:
- Neurology
- Endocrinology
- Diabetology
Background:
- Diabetic neuropathy is a prevalent complication of diabetes mellitus.
- It significantly contributes to patient morbidity and mortality.
- Hyperglycemia is the primary risk factor for its development.
Purpose of the Study:
- To review the epidemiology, classification, pathology, and treatment of diabetic neuropathy.
- To provide an overview of current therapeutic strategies for managing diabetic neuropathy symptoms.
Main Methods:
- Literature review of epidemiological data, pathological mechanisms, and clinical trial evidence.
- Synthesis of information on drug efficacy for symptomatic management and disease modification.
Main Results:
- Diabetic peripheral neuropathy affects approximately 30% of hospitalized and 20% of community-dwelling diabetes patients.
- Sensorimotor neuropathy presents with pain and sensory loss; autonomic neuropathies affect cardiac, gastrointestinal, and genitourinary functions.
- Numerous medications are supported by evidence for symptom management, with ruboxistaurin showing promise as a disease-modifying therapy.
Conclusions:
- Diabetic neuropathy is a complex condition with diverse clinical manifestations.
- Symptomatic management is achievable with a wide range of pharmacological agents.
- Optimal glycemic control is fundamental for both prevention and treatment of diabetic neuropathy.
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