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Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats

Maria Luisa Sotgiu1, Paola Bellomi, Gabriele E M Biella

  • 1Istituto Bioimmagini e Fisiologia Molecolare, CNR, Via Fratelli Cervi 93, 20090 Segrate (Mi), Italy. maria.luisa.sotgiu@ibfm.cnr.it

Brain Research
|January 31, 2004
PubMed

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Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...