Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium sulphate-based cements containing cephalexin.

J C Doadrio1, D Arcos, M V Cabañas

  • 1Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain.

Biomaterials
|January 31, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From bone replacement to regeneration. A biomaterials started journey.

Materials today. Bio·2026
Same author

Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid.

Acta biomaterialia·2025
Same author

New materials and complications of prostheses in humans: situation in Spain.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2024
Same author

Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo.

Acta biomaterialia·2024
Same author

[Translated article] Design and comparison of bone substitutes. Study of in vivo behaviour in a rabbit model.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Desing and comparison of bone substitutes. Study of in vivo behavior in a rabbit model.

Revista espanola de cirugia ortopedica y traumatologia·2023

New gypsum and apatite/gypsum cements incorporating cephalexin (antibiotic) function as effective drug delivery systems. The cement composition influences the rate of cephalexin release in simulated body fluid.

Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Drug Delivery Systems

Background:

  • Development of advanced biomaterials for controlled drug release is crucial for therapeutic applications.
  • Gypsum and apatite-based cements are investigated for their potential in biomedical fields.
  • Incorporation of antibiotics into cementitious materials can prevent post-surgical infections.

Purpose of the Study:

  • To synthesize gypsum and apatite/gypsum cements containing cephalexin.
  • To evaluate the physico-chemical properties and structural integrity of these composite cements.
  • To assess the drug release kinetics and behavior of the cements as drug delivery systems in simulated body fluid.

Main Methods:

  • Synthesis of gypsum and apatite/gypsum cements with embedded cephalexin.

Related Experiment Videos

  • Characterization of cement physico-chemical properties and structural analysis.
  • In vitro drug release studies using simulated body fluid (SBF).

    • Main Results:

    • Cephalexin incorporation did not alter cement physico-chemical behavior or structure.
    • Both cement types acted as drug delivery systems, releasing cephalexin in SBF.
    • Gypsum cements showed rapid cephalexin release, while apatite/gypsum cements exhibited controlled release influenced by hydroxyapatite.

    Conclusions:

    • Cephalexin-loaded gypsum and apatite/gypsum cements are viable for drug delivery applications.
    • The presence of hydroxyapatite in the cement matrix modulates the cephalexin release profile.
    • Apatite-containing cements demonstrated improved properties, including lower viscosity and faster in vitro apatite layer formation.