Onychomycosis caused by Aspergillus terreus

Area of Science:

• Medical Mycology
• Dermatology

Background:

• Onychomycosis is a common nail infection.
• Aspergillus species are increasingly recognized as causative agents of onychomycosis.

Observation:

• Four cases of onychomycosis attributed to Aspergillus terreus are presented.
• Clinical signs included spotted/striated leuconychia, dark spots, and nail fragility.
• Aspergillus terreus demonstrated inhibitory effects on dermatophytes and Scopulariopis brevicaulis growth in vitro.

Findings:

• Topical treatment with 1% Pimafucin in a 60% dimethylsulfoxide (DMSO) and 40% water mixture was effective.
• A 9% aqueous solution of sodium benzoate also proved effective in treating these cases.
• The study summarizes existing literature on Aspergillus terreus onychomycosis.

Implications:

• Highlights Aspergillus terreus as a pathogen in onychomycosis.
• Suggests novel and effective topical treatment options for challenging nail fungal infections.
• Informs clinical practice regarding diagnosis and management of Aspergillus-related onychomycosis.