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Immunotherapy in children.

Ulrich Wahn1

  • 1Department of Pediatric Pneumology and Immunology, CHARITE Humboldt-University, Berlin, Germany. ulrich.wahn@charite.de

Current Opinion in Allergy and Clinical Immunology
|January 31, 2004
PubMed
Summary
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Specific allergen immunotherapy shows promise in modifying allergic airway disease in children. However, current evidence for sublingual immunotherapy is insufficient for widespread clinical practice recommendations.

Area of Science:

  • Allergy and Immunology
  • Pediatric Pulmonology

Background:

  • Specific allergen immunotherapy (AIT) has a long history, with ongoing clinical trials exploring its efficacy.
  • Sublingual allergen application is gaining interest for pediatric allergy treatment.

Purpose of the Study:

  • To review the current evidence on specific allergen immunotherapy, particularly in children.
  • To assess the potential of AIT to alter the natural course of allergic airway diseases.

Main Methods:

  • Review of controlled long-term clinical trials on specific allergen immunotherapy.
  • Evaluation of evidence regarding sublingual immunotherapy (SLIT) in pediatric populations.

Main Results:

  • AIT may reduce new allergies, long-term allergic symptoms, and asthma incidence.

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  • Current evidence for SLIT is not sufficient to support its routine clinical use in children.

    • Conclusions:

    • Specific allergen immunotherapy is a consideration for children with IgE-mediated allergic symptoms unresponsive to symptomatic treatment.