Related Experiment Video
Updated: Jun 18, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
[Pleomorphic carcinoma of the large intestine]
Agathe Régnier1, Catherine Julié, Ute Zimmermann
1Service d'Anatomie Pathologique, CHU Ambroise Paré (AP-HP), Boulogne-Billancourt.
Abstract:
Pleomorphic carcinoma, firstly described in the lung, is exceptional in the digestive tract. This tumor is often associated with fever and peripheral blood leukocytosis. The histological feature is characterized by giant pleomorphic often multinucleated cells with dense neutrophil infiltration and frequent phagocytosis of neutrophils by the tumor cells. Expression of epithelial markers confirm the diagnosis. The prognosis is very poor. We hereby report one case of pleomorphic carcinoma unusually situated in the large intestine, emphasizing difficulties encountered in establishing diagnosis.
More Related Videos
Related Concept Videos
Renewal of Intestinal Stem Cells
Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Large Intestine
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
Histology of the Large Intestine
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
Cellular Adaptation IV: Dysplasia and Metaplasia
Diverticular Disease of the Colon

