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[Invasive hydatiform mole in a postmenopausal woman]
Arnaud de la Fouchardière1, Alexandre Cassignol, Leila Benkiran
1Service d'anatomie et cytologie pathologiques, Hôpital de la Croix Rousse, Lyon.
Annales De Pathologie
|January 31, 2004
Summary
Gestational trophoblastic disease is rare in postmenopausal women. This case highlights an invasive mole following a pregnancy after menopause, challenging typical disease origins.
Area of Science:
- Gynecology
- Oncology
- Reproductive Endocrinology
Background:
- Gestational trophoblastic disease (GTD) is uncommon in postmenopausal women.
- Invasive moles require differentiation from choriocarcinoma through histological examination.
- GTD in this demographic may arise from latent remnants or a current pregnancy.
Observation:
- A 51-year-old postmenopausal woman presented with an invasive complete mole.
- The patient exhibited an ovarian corpus luteum, suggesting a recent pregnancy.
- This diagnosis followed a confirmed pregnancy after biological menopause.
Findings:
- The case presents an invasive mole in a postmenopausal woman.
- Histological analysis revealed infiltrative molar villi and significant trophoblastic proliferation.
- The GTD was linked to a pregnancy occurring after menopause.
Implications:
- This case expands the understanding of GTD origins in postmenopausal women.
- It underscores the possibility of pregnancy and subsequent GTD after menopause.
- Further research is needed to elucidate the mechanisms of postmenopausal GTD.