[Epithelioid hemangioma of bone: a rare pathologic entity]
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Updated: Aug 29, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Ammar Bouziani1, Ilhem Bettaieb, Fethi Bougrine
1Service d'Anatomie et de Cytologie Pathologiques, Hôpital Militaire Principal d'instruction de Tunis, 1008 Monfleury, Tunis.
Abstract:
Epithelioid hemangioma of bone is a rare benign vascular lesion. Since its first description by Rosai in 1979 about thirty cases have been reported. We report two new cases diagnosed in patients aged 21 and 7 years. Both patients had multiple lesions on the legs. Bone pain was the main symptom. Routine laboratories studies were unremarkable. Bon radiographs showed an expansive process of the bone. Histological and immunochemical features were typical of epithelioid hemangioma of the bone. Treatment consisted in above knee amputation for the first patient and therapeutic abstention for the second. Both patients are alive without progressive local disease or metastasis.
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