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Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier
Published on: October 26, 2013
Very early expression of vascular endothelial growth factor in brain oedema tissue associated with brain contusion
R Suzuki1, N Fukai, G Nagashijma
1Department of Neurosurgery, Showa University, Fujigaoka Hospital, Japan. ryuta@med.showa-u.ac.jp
Background:
Brain oedema associated with cerebral contusion can be life-threatening. Mechanisms of the development of brain oedema are still unclear.
Method:
We investigated the expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (KDR/Flk-1) in the contusional brain tissue obtained during neurosurgery from 5 patients.
Findings:
VEGF is expressed in some but not all the astrocytes, and KDR/Flk-1 is expressed in vascular endothelial cells in the con-tusional tissue as early as 3 hours after onset.
Conclusion:
The results suggested that the VEGF is induced in the contusional tissue in the very early period after onset, and that it increases capillary permeability via KDR/Flk-1 resulting in vasogenic type brain oedema.
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