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Updated: Jan 30, 2026

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Published on: September 9, 2020
Spontaneous oscillations of dressed neurons: a new mechanism for epilepsy?
1Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens Ohio 45701, USA.
Abstract:
Most modeling studies of neurons and neuronal networks are based on the assumption that the neurons are isolated from their normal environment. Based on recent experimental data we put forward a model for neurons that incorporates the influence of the surrounding glia (dressed neurons). We predict seizurelike spontaneous oscillations in the absence of stimuli for strong coupling between neurons and astrocytes. Consistent with our predictions, a signature of this enhanced crosstalk, over expression of glutamate receptors in astrocytes, has been observed specifically in epileptic tissue.
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