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Updated: Aug 29, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
Published on: December 24, 2015
Dendritic cell endothelium interaction in autoimmunity
C L Schlichting1, W D Schareck, M Weis
1Department of Surgery, Devision of Transplantation Surgery, School of Medicine, University Hospital, University Rostock, Schillingalle 35, 18055 Rostock, Germany. christoph.schlichting@drschlichting.de
Abstract:
Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.
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