Related Experiment Video
Updated: Feb 1, 2026
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
8.0K
Angiogenesis: a target for cancer therapy.
Giampaolo Tortora1, Davide Melisi, Fortunato Ciardiello
1Division of Medical Oncology, Department of Molecular and Clinical Endocrinology and Oncology, Università di Napoli Federico II, Via S. Pansini 5, 80131 Naples, Italy. gtortora@unina.it
Current Pharmaceutical Design
|February 3, 2004
Summary
New antiangiogenic drugs targeting tumor neoangiogenesis are emerging. Optimizing their combination with conventional therapies requires further research into treatment timing and sequencing.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Neoangiogenesis, the formation of new blood vessels, is crucial for tumor growth and spread.
- Identifying key molecules in neoangiogenesis has led to targeted antiangiogenic agents.
- Integrating antiangiogenic drugs with standard treatments is promising but requires optimized strategies.
Purpose of the Study:
- To review the signal transduction pathways of angiogenic molecules.
- To discuss the development and clinical translation of specific antiangiogenic inhibitors.
- To explore future perspectives in antiangiogenic therapy.
Main Methods:
- Literature review of signal transduction mechanisms.
- Analysis of clinical studies on antiangiogenic inhibitors.
- Discussion of emerging therapeutic strategies.
Main Results:
- Detailed overview of molecular mechanisms driving neoangiogenesis.
- Summary of clinical trial outcomes for various antiangiogenic agents.
- Identification of challenges and opportunities in combined treatment protocols.
Conclusions:
- Antiangiogenic therapy holds significant potential in cancer treatment.
- Further investigation is needed to determine optimal combination strategies and timing.
- Future research should focus on novel targets and personalized approaches to antiangiogenic therapy.
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