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[Adverse drug reactions: Naranjo's and Venulet's algorithms]

G Tiberio López1, J Hueto Pérez de Heredia, M Moreno Baquedano

  • 1Servicio de Medicina Interna y Farmacología, Hospital Virgen del Camino, Pamplona.

Revista Clinica Espanola
|October 1, 1992
PubMed

Insights

This study evaluated adverse drug experiences (ADEs) in respiratory patients, finding theophyllines, beta-mimetics, and antibiotics were common culprits. Most ADEs caused mild symptoms like nausea or skin issues, with no fatalities reported.

Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacy
  • Internal Medicine

Background:

  • Adverse drug experiences (ADEs) pose a significant challenge in hospitalized patients.
  • Monitoring ADEs is crucial for patient safety and optimizing pharmacotherapy.

Purpose of the Study:

  • To prospectively evaluate the incidence and characteristics of ADEs in patients admitted to a respiratory unit.
  • To identify the most frequent drug classes associated with ADEs and their clinical manifestations.

Main Methods:

  • Prospective data collection of ADEs in a general hospital's respiratory section.
  • Analysis of patient demographics, drug culprits, and symptomology.
  • Utilized Naranjo's and Venulet's algorithms for causality assessment.

Main Results:

  • 32 ADEs were documented, representing 14.6% of patients.
  • Theophyllines, beta-mimetics, and antibiotics were the most implicated drug classes.
  • Gastrointestinal (epigastralgia-nausea, 40.6%) and dermatological (18.75%) reactions were most common.
  • No deaths were attributed to ADEs; only 9 cases required specific treatment.
  • Naranjo's and Venulet's algorithms yielded non-comparable results.

Conclusions:

  • ADEs are relatively common in respiratory inpatients, primarily linked to common respiratory medications.
  • The majority of ADEs are mild and manageable, with a low rate of severe outcomes.
  • Further research is needed to compare the utility of different causality assessment algorithms for ADEs.

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