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Updated: Aug 29, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Ischemia induces short- and long-term remodeling of synaptic activity in the hippocampus
Valérie Crepel1, J Epsztein, Y Ben-Ari
1INMED, INSERM U.29 & Université de La Méditerranée, Parc scientifique de Luminy, Marseille, France. crepel@inmed.univ-mrs.fr
Abstract:
One of the most vulnerable areas to ischemia or hypoglycemia is CA1 hippocampal region due to pyramidal neurons death. Glutamate receptors are involved together with protein-kinase C and nitric oxide synthase. Long-term potentiation (LTP) is generated in anoxic or hypoglycemic conditions via activation of NMDA while inhibition of these receptors attenuates this response. Protein-kinase C and nitric oxide synthase are involved in anoxic LTP mechanism. Postischemic neurons are hyperexcitable in CA3 area while CA1 pyramidal neurons degenerate and disappear. Changes of glutamate receptors triggered by ischemia and hypoglycemia are discussed in this review.
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