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Genetic clock of biologic rhythms.

C Badiu1

  • 1Department of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. badicrin@yahoo.co.uk

Journal of Cellular and Molecular Medicine
|February 3, 2004
PubMed
Summary

Biological rhythms are controlled by genetic clockwork in all species. This review details mammalian clock genes, their interactions, and roles in peripheral tissues, presenting a model of cellular clock mechanisms.

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Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Background:

  • Biologic rhythms are essential for species adaptation to environmental changes.
  • These rhythms are regulated by an intrinsic genetic clockwork mechanism.
  • Mammalian clock genes form a complex regulatory network.

Purpose of the Study:

  • To review mammalian clock genes and their interrelations.
  • To present a model integrating cell clock gene characteristics.
  • To discuss the involvement of clock genes in peripheral tissues.

Main Methods:

  • Literature review of mammalian clock genes.
  • Analysis of gene promoter interactions (e.g., CLOCK/BMAL1 and PER proteins).
  • Integration of cellular clock gene characteristics into a model.

Main Results:

  • The CLOCK/BMAL1 heterodimer stimulates PER gene promoter activity.
  • The regulatory feedback loop involving PER/CRY heterodimers is complex.
  • Clock genes play a role in peripheral tissues.

Conclusions:

  • Mammalian clock gene regulation is intricate, involving complex feedback loops.
  • A model integrating cellular clock gene characteristics has been developed.
  • Clock genes are crucial for biological rhythm regulation in peripheral tissues.

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