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[T-lymphomas with splenic presentation].

G Obeso1, E Cuevas, C Ortiz

  • 1Departamento de Anatomía Patológica, Universidad Autónoma de Madrid.

Revista Clinica Espanola
|November 1, 1992
PubMed
Summary
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Splenomegaly as the initial sign of lymphoma, without swollen lymph nodes, is rare. Diagnosis often requires surgery, revealing primary splenic lymphoma or lymphoma linked to hemophagocytosis.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Lymphomas can present with splenomegaly (enlarged spleen) as an early symptom.
  • Peripheral lymphadenopathy (swollen lymph nodes) is a common initial sign of lymphoma.
  • Splenic lymphomas are a less common but significant group of lymphoproliferative disorders.

Observation:

  • Three cases of lymphoma with splenomegaly as the primary presenting feature are analyzed.
  • These cases lacked peripheral adenopathies, complicating initial diagnosis.
  • Surgical intervention (laparotomy) was necessary for definitive diagnosis in all three cases.

Findings:

  • One case presented as primary splenic lymphoma.
  • Two cases were associated with reactive hemophagocytosis, a serious condition where the immune system over-activates.

Related Experiment Videos

  • The study highlights the diagnostic challenge of splenic lymphomas presenting without peripheral signs.

    • Implications:

    • Emphasizes the need to consider splenic lymphoma in differential diagnoses of unexplained splenomegaly.
    • Suggests that laparotomy may be crucial for diagnosing certain lymphomas.
    • Contributes to understanding the spectrum of lymphoproliferative processes with predominant splenic involvement.