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Active deep brain stimulation during MRI: a feasibility study.

J-C Georgi1, C Stippich, V M Tronnier

  • 1Division of Neuroradiology, Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany. jens.geordi@med.uni-heidelberg.de

Magnetic Resonance in Medicine
|February 3, 2004
PubMed
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Active deep brain stimulation (DBS) during MRI poses risks like heating and induced voltage. However, with specific safety measures, MRI scans with active DBS are feasible, enhancing patient safety during neuroimaging.

Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) is a crucial therapy for neurological disorders.
  • Magnetic Resonance Imaging (MRI) offers advanced diagnostic capabilities.
  • Simultaneous use of DBS and MRI presents potential safety concerns due to electromagnetic interactions.

Purpose of the Study:

  • To assess the feasibility and safety of performing functional MRI (fMRI) with active deep brain stimulation (DBS).
  • To identify and evaluate potential hazards associated with active DBS during standard clinical MRI sequences.
  • To determine conditions and necessary precautions for safe co-application of DBS and MRI.

Main Methods:

  • Phantom measurements using a DBS electrode and lead in a saline solution.

Related Experiment Videos

  • Application of standard clinical MRI sequences including diffusion-weighted imaging, perfusion-weighted imaging, fMRI, and morphologic MRI.
  • Monitoring of induced voltage, electrode tip temperature, lead temperature, forces, and neurostimulator operation under active DBS.

    • Main Results:

    • Significant hazards were observed, including severe heating at electrode tips and induced voltages.
    • Sparking occurred at defects in the connecting cable, indicating potential risks.
    • Image quality was assessed across various MRI sequences during active DBS.
    • Despite risks, the study demonstrated that safe MRI examinations with active DBS are achievable under specific conditions.

    Conclusions:

    • Active DBS during MRI poses significant safety risks, including thermal effects and electrical hazards.
    • Implementing specific safety precautions is essential for mitigating these risks.
    • Conditional feasibility of safe MRI examinations during active DBS was established, guiding clinical practice.